Population genetic structure and natural selection of apical membrane antigen-1 in Plasmodium vivax Korean isolates
نویسندگان
چکیده
منابع مشابه
Analysis of Plasmodium vivax Apical Membrane Antigen-1 (PvAMA-1) Haplotypes among Iranian Isolates
Plasmodium vivax apical membrane antigen-1(PvAMA-1) is a surface protein with polymorphic sites. This study was aimed to analyze the polymorphic amino acid residues at PvAMA-1 in different infected age groups. 92 blood samples were collected from south and southeast of Iran. The DNA coding for the domain I (DI), DII, and partial DIII of this antigen was amplified by Nested-PCR, and sequenced. N...
متن کاملGenetic diversity and effect of natural selection at apical membrane antigen-1 (AMA-1) among Iranian Plasmodium vivax isolates.
Apical membrane antigen-1 (AMA-1) of Plasmodium vivax Grassi et Feletti, 1890 is a promising malaria vaccine candidate. However, antigenic variation is a major problem to design a universal malaria vaccine. Hence, detailed understanding of the pvama-1 gene polymorphism can provide conductive information on this potential vaccine component. Therefore, this study investigated the extent of geneti...
متن کاملGenetic diversity and selection at the Plasmodium vivax apical membrane antigen-1 (PvAMA-1) locus in a Sri Lankan population.
Plasmodium vivax apical membrane antigen 1 (PvAMA-1) is an important malaria vaccine candidate. We present the first comprehensive analysis of nucleotide diversity across the entire PvAMA-1 gene using a single population sample from Sri Lanka. In contrast to what has been observed at the AMA-1 locus of Plasmodium falciparum, the signature of diversifying selection is seen most strongly in Domai...
متن کاملgenetic variation and selection of domain i of the plasmodium vivax apical membrane antigen-1(ama-1) gene in clinical isolates from iran.
background: apical membrane antigen 1 (ama-1) is positioned on the surface of merozoite and it may play a role in attack to red blood cells. the mainaim of present study was to determine the genetic variation, as well as, to detect of selection at domain i of ama-1 gene plasmodium vivax isolates in iran. methods: blood samples were collected from 58 patients positive for p. vivax ,mono infectio...
متن کاملHeterologous expression of Plasmodium vivax apical membrane antigen 1 (PvAMA1) for binding peptide selection
BACKGROUND Plasmodium is an obligate intracellular parasite. Apical membrane antigen 1 (AMA1) is the most prominent and well characterized malarial surface antigen that is essential for parasite-host cell invasion, i.e., for sporozoite to invade and replicate within hepatocytes in the liver stage and merozoite to penetrate and replicate within erythrocytes in the blood stage. AMA1 has long serv...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Malaria Journal
سال: 2015
ISSN: 1475-2875
DOI: 10.1186/s12936-015-0942-6